Journal
ACS MEDICINAL CHEMISTRY LETTERS
Volume 1, Issue 2, Pages 59-63Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ml900025z
Keywords
Hematopoietic prostaglandin D synthase (HPGDS); PGH(2); PGD(2); airway allergy; inflammatory processes; cyclooxygenase (COX)
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Hematopoietic prostaglandin D synthase (HPGDS) is primarly expressed in mast cells, antigen-presenting cells, and Th-2 cells. HPGDS converts PGH(2) into PGD(2), a mediator thought to play a pivotal role in airway allergy and inflammatory processes. In this letter, we report the discovery of an orally potent and selective inhibitor of HPGDS that reduces the antigen-induced response in allergic sheep.
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