Journal
WILEY INTERDISCIPLINARY REVIEWS-SYSTEMS BIOLOGY AND MEDICINE
Volume 3, Issue 5, Pages 544-561Publisher
WILEY
DOI: 10.1002/wsbm.136
Keywords
-
Categories
Funding
- NIH [P50GM076547, 1R01GM077398-01A2]
- DoE [ENIGMA MAGIC DE-FG02-07ER64327]
- NSF [DBI-0640950]
Ask authors/readers for more resources
The evolutionary success of an organism is a testament to its inherent capacity to keep pace with environmental conditions that change over short and long periods. Mechanisms underlying adaptive processes are being investigated with renewed interest and excitement. This revival is partly fueled by powerful technologies that can probe molecular phenomena at a systems scale. Such studies provide spectacular insight into the mechanisms of adaptation, including rewiring of regulatory networks via natural selection of horizontal gene transfers, gene duplication, deletion, readjustment of kinetic parameters, and myriad other genetic reorganizational events. Here, we discuss advances in prokaryotic systems biology from the perspective of evolutionary principles that have shaped regulatory networks for dynamic adaptation to environmental change. (C) 2010 John Wiley & Sons, Inc. WIREs Syst Biol Med 2011 3 544-561 DOI: 10.1002/wsbm.136
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available