Journal
AUTOPHAGY
Volume 11, Issue 12, Pages 2377-2378Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/15548627.2015.1106665
Keywords
Atg39; Atg40; ER-phagy; nitrogen starvation; nucleophagy; selective autophagy; yeast
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Funding
- Grants-in-Aid for Scientific Research [25711005, 25111001, 25111003, 15J11855] Funding Source: KAKEN
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Autophagy targets various intracellular components ranging from proteins and nucleic acids to organelles for their degradation in lysosomes or vacuoles. In selective types of autophagy, receptor proteins play central roles in target selection. These proteins bind or localize to specific targets, and also interact with Atg8 family proteins on forming autophagosomal membranes, leading to the efficient sequestration of the targets by the membranes. Our recent study revealed that yeast cells actively degrade the endoplasmic reticulum (ER) and even part of the nucleus via selective autophagy under nitrogen-deprived conditions. We identified novel receptors, Atg39 and Atg40, specific to these pathways. Here, we summarize our findings on reticulophagy' (or ER-phagy') and nucleophagy', and discuss key issues that remain to be solved in future studies.
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