Journal
EXPERIMENTAL AND THERAPEUTIC MEDICINE
Volume 6, Issue 5, Pages 1317-1321Publisher
SPANDIDOS PUBL LTD
DOI: 10.3892/etm.2013.1297
Keywords
curcumin; cisplatin; cancer stem cells; laryngeal carcinoma
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Funding
- National Natural Science Foundation of China [30973288]
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Chemoresistance is one of the major barriers to chemotherapeutic treatment and it has been established that CD133(+) cancer stem cells are responsible for drug resistance in laryngeal carcinoma. In the present study, curcumin and cisplatin were used as a combined treatment to induce the sensitivity of CD133(+) cancer stern cells to chemotherapeutic agents and to enhance therapeutic effectiveness. The results revealed that in untreated and cisplatin-treated HEp-2 cell groups, the percentage of CD133(+) cells was 4.50 and 6.89%, respectively. However, in the combined treatment group, the percentage of CD133(+) cells was markedly reduced to 1.49%, indicating that curcumin may increase the sensitivity of CD133(+) cells to cisplatin, leading to the suppression of chemoresistance in HEp-2 cells. Furthermore, the expression of ATP-binding cassette sub-family G member 2 (ABCG2), which is an important gene for chemoresistance, was demonstrated to be reduced in CD133(+) cancer stem cells following combined treatment. These results suggest that the combined application of curcumin with chemotherapeutic drugs may be a reliable and effective approach for the treatment of laryngeal carcinoma,
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