Journal
EXPERIMENTAL AND THERAPEUTIC MEDICINE
Volume 3, Issue 2, Pages 357-361Publisher
SPANDIDOS PUBL LTD
DOI: 10.3892/etm.2011.410
Keywords
Notch signaling; cisplatin resistance; nasopharyngeal carcinoma
Categories
Funding
- National Natural Science Foundation of China [30872851, 30901662]
- Science and Technology Department of Hubei Province [2007AA302B08]
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The Notch signaling pathway plays an important role in the proliferation and differentiation of cells. Although recent studies have shown that Notch plays a role in the mechanisms of cisplatin resistance, the mechanism by which Notch plays roles in intrinsic or acquired cisplatin resistance remains unclear. In the present study, poorly differentiated nasopharyngeal carcinoma cells were treated with a gamma-secretase inhibitor (DAPT), which led to a decrease in the Notch intracellular domain and inhibition of Notch signaling. Treatment was not sufficient to induce pronounced apoptosis of CNE-2 cells, but did result in the down-regulation of the P-glycoprotein and ERCC1 protein. In contrast, the combined treatment of DAPT and cisplatin induced substantial cell apoptosis compared to cisplatin treatment alone.
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