Journal
EXPERIMENTAL AND THERAPEUTIC MEDICINE
Volume 3, Issue 1, Pages 146-148Publisher
SPANDIDOS PUBL LTD
DOI: 10.3892/etm.2011.365
Keywords
curcumin; ultrasound; mitophagy; autophagic cell death; nasopharyngeal carcinoma
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Funding
- National Nature Science Foundation of China [30973168]
- Affiliated Hospital of Xi'an Medical University [XYFY10-02]
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The present study was designed to observe the initiation of mitophagy in tumor cells after ultrasound treatment in the presence of curcumin under transmission electron microscopy. Nasopharyngeal carcinoma CNE2 cells were incubated with 10 mu M curcumin and then exposed to ultrasound for 8 sec at an intensity of 0.46 W/cm(2). Severely swollen mitochondria, disrupted mitochondria and mitophagy were noted in the CNE2 cells after ultrasound treatment in the presence of curcumin. Our findings demonstrated that ultrasound treatment in the presence of curcumin significantly initiated mitophagy in CNE2 cells, which suggests that mitophagy serves as an important event in the process of cell death of nasopharyngeal carcinoma cells.
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