Journal
EXPERIMENTAL AND THERAPEUTIC MEDICINE
Volume 1, Issue 2, Pages 257-264Publisher
SPANDIDOS PUBL LTD
DOI: 10.3892/etm_00000040
Keywords
cyclooxygenase-2; peroxisome proliferator-activated receptor gamma; prostaglandins; nonsteroidal anti-inflammatory drugs
Categories
Funding
- Czech Science Foundation [301/09/1115, 204/08/H054]
- Ministry of Education, Youth and Sports of the Czech Republic [MSM0021622415]
- Masaryk University [MUNI/0099/2009]
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Increased production of the pro-inflammatory enzyme cyclooxygenase-2 (Cox-2) and altered expression and activity of peroxisome proliferator-activated receptor gamma (PPAR gamma) have been observed in many malignancies. Both the PPAR gamma ligands and the Cox-2 inhibitors possess anti-inflammatory and anti-neoplastic effects in vitro and have been assessed for their therapeutic potential in several pre-clinical and clinical studies., Recently, multiple interactions between PPAR gamma and Cox-2 signaling pathways have been revealed. Understanding of the cross-talk between PPAR gamma and Cox-2 might provide important novel strategies for the effective treatment and/or prevention of cancer. This article summarizes recent achievements involving the functional interactions between the PPAR gamma and Cox-2 signaling pathways and discusses the implications of such interplay for clinical use.
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