Journal
EXPERIMENTAL AND THERAPEUTIC MEDICINE
Volume 1, Issue 4, Pages 585-590Publisher
SPANDIDOS PUBL LTD
DOI: 10.3892/etm_00000092
Keywords
extracellular superoxide dismutase; oral squamous-cell carcinoma; immunohistochemistry; lymph node metastasis; aggressive phenotype
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Funding
- Ministry of Education, Culture, Sports, Science and Technology of Japan [20791492]
- Global Center for Education and Research in Immune System Regulation and Treatment, MEXT, Japan
- Grants-in-Aid for Scientific Research [20791492] Funding Source: KAKEN
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Oxidative stress results in damage to cellular structures and has been linked to numerous diseases, including cancer. Extracellular superoxide dismutase (EC-SOD) is a principal enzymatic antioxidant in extracellular space. The purpose of this study was to determine whether the expression of EC-SOD protein is altered in the carcinogenetic process of oral squamous-cell carcinoma (OSCC). Immunohistochemical analysis was carried out in matched normal and tumour specimens collected from 58 OSCCs and 20 oral premalignant lesions (OPLs). Correlations between the EC-SOD expression levels and clinicopathological features of OSCC patients were evaluated by Fisher's exact test. Although EC-SOD protein was consistently expressed on the plasma membrane of cells in normal tissues, plasma membranous EC-SOD expression was lost in almost all the OSCC specimens examined (98%). Instead, positive EC-SOD expression was detected in the cytoplasmic compartments of cancerous cells in both OPLs (65%) and OSCCs (52%), together with a high incidence of lymph node metastasis (p=0.0397). These results suggest that the dysregulation of EC-SOD protein expression is a frequently occuring and early event in oral carcinogenesis, and that cytoplasmic EC-SOD may contribute to the increased aggressiveness of OSCC.
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