Journal
PPAR RESEARCH
Volume 2010, Issue -, Pages -Publisher
HINDAWI LTD
DOI: 10.1155/2010/417646
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Funding
- National Science Council of Taiwan
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Peroxisome proliferator-activated receptors (PPARs) were reported to prevent cells from stress-induced apoptosis and protect tissues against ischemia-reperfusion injury. The underlying transcriptional mechanism is unclear. Recent reports indicate that the antiapoptotic actions of ligand-activated PPARd and PPAR. are mediated through enhanced binding of PPAR to the promoter of 14-3-3 epsilon and upregulation of 14-3-3 epsilon expression. We propose that ligand-activated PPAR alpha exerts its anti-apoptotic actions via the identical pathway. The PPAR to 14-3-3 transcriptional axis plays an important role in protection of cell and tissue integrity and is a target for drug discovery.
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