Journal
PPAR RESEARCH
Volume 2009, Issue -, Pages -Publisher
HINDAWI LTD
DOI: 10.1155/2009/543746
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Funding
- Merck Sharp & Dohme-Chibret (France)
- Department of Health and Social Service (Northern Ireland)
- Fondation de France
- Donald W. Reynolds Foundation
- ESRC [ES/G007438/1] Funding Source: UKRI
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL087647] Funding Source: NIH RePORTER
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Single nucleotide polymorphisms (SNPs) in the peroxisome proliferator-activated receptor gamma (PPARG) gene have been associated with cardiovascular risk factors, particularly obesity and diabetes. We assessed the relationship between 4 PPARG SNPs (C-681G, C-689T, Pro12Ala, and C1431T) and coronary heart disease (CHD) in the PRIME (249 cases/494 controls, only men) and ADVANCE (1,076 cases/805 controls, men or women) studies. In PRIME, homozygote individuals for the minor allele of the PPARG C-689T, Pro12Ala, and C1431T SNPs tended to have a higher risk of CHD than homozygote individuals for the frequent allele (adjusted OR [95% CI] = 3.43 [0.96-12.27], P =.058, 3.41 [0.95-12.22], P=.060 and 5.10 [0.99-26.37], P=.050, resp.). No such association could be detected in ADVANCE. Haplotype distributions were similar in cases and control in both studies. A meta-analysis on the Pro12Ala SNP, based on our data and 11 other published association studies (6,898 CHD cases/11,287 controls), revealed that there was no evidence for a significant association under the dominant model (OR = 0.99 [0.92-1.07], P=.82). However, there was a borderline association under the recessive model (OR = 1.29 [0.99-1.67], P=.06) that became significant when considering men only (OR = 1.73 [1.20-2.48], P=.003). In conclusion, the PPARG Ala12Ala genotype might be associated with a higher CHD risk in men but further confirmation studies are needed. Copyright (C) 2009 Jean Dallongeville et al.
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