Journal
ALTEX-ALTERNATIVES TO ANIMAL EXPERIMENTATION
Volume 29, Issue 2, Pages 119-128Publisher
SPEKTRUM AKADEMISCHER VERLAG-SPRINGER-VERLAG GMBH
DOI: 10.14573/altex.2012.2.119
Keywords
systems toxicology; metabolomics; mechanistic toxicology; pathways of toxicity; toxicogenomics
Categories
Ask authors/readers for more resources
The need for a more mechanistic understanding of the ways in which chemicals modulate biological pathways is urgent if we are to identify and better assess safety issues relating to a wide range of substances developed by the pharmaceutical, chemical, agri-bio, and cosmetic industries. lilies technologies provide valuable opportunity to refine existing methods and provide information for so-called integrated testing strategies via the creation of signatures of toxicity. By mapping these signatures to underlying pathways of toxicity, some of which have been identified by toxicologists over the last few decades, and bringing them together with pathway information determined from biochemistry and molecular biology, a systems toxicology approach will enable virtual experiments to be conducted that can improve the prediction of hazard and the assessment of compound toxicity.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available