Journal
SAUDI PHARMACEUTICAL JOURNAL
Volume 19, Issue 2, Pages 65-74Publisher
ELSEVIER
DOI: 10.1016/j.jsps.2011.01.007
Keywords
Adiantum capillus-veneris L.; Adiantane; Filicane triterpenoids; Flavonoids; Anti-inflammatory; Hypoglycemic
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Chromatographic fractionation of the alcoholic extract of the dried fronds of Adiantum capillus-veneris L. (Adiantaceae) yielded seven compounds: four triterpenoidal compounds belonging to adiantane and filicane groups were isolated from the hexane fraction and identified as isoadiantone (1); isoadiantol-B (2); 3-methoxy-4-hydroxyfilicane (3) and 3,4-dihydroxyfilicane (4) and three flavonoids were isolated from the ethyl acetate fraction and identified as: quercetin (5), quercetin-3-O-glucoside (6) and quercetin-3-O-rutinoside (rutin) (7). The identification of the isolated compounds has been established through their physical, chemical and spectroscopic methods including IR, H-1 NMR, C-13 NMR, HSQC, HMBC, NOESY and MS. Biological studies of the total alcoholic extract, hexane fraction and some of the isolated compounds showed an anti-inflammatory activity while the hypoglycemic study of the total alcoholic extract showed a significant activity. (C) 2011 King Saud University. Production and hosting by Elsevier B.V. All rights reserved.
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