Journal
INTERNATIONAL JOURNAL OF ORAL SCIENCE
Volume 2, Issue 3, Pages 117-126Publisher
SPRINGERNATURE
DOI: 10.4248/IJOS10042
Keywords
salivary gland; epithelium; branching morphogenesis; fibronectin; E-cadherin; growth factor
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Funding
- National Institute of Dental and Craniofacial Research, NIH
- NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH [ZIADE000525] Funding Source: NIH RePORTER
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Salivary glands provide saliva to maintain oral health, and a loss of salivary gland function substantially decreases quality-of-life. Understanding the biological mechanisms that generate salivary glands during embryonic development may identify novel ways to regenerate function or design artificial salivary glands. This review article summarizes current research on the process of branching morphogenesis of salivary glands, which creates gland structure during development. We highlight exciting new advances and opportunities in studies of cell-cell interactions, mechanical forces, growth factors, and gene expression patterns to improve our understanding of this important process.
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