Related references
Note: Only part of the references are listed.Targeting PIM kinase activity significantly augments the efficacy of cytarabine
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MOLECULAR CANCER THERAPEUTICS (2009)
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Pim-1 plays a pivotal role in hypoxia-induced chemoresistance
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ONCOGENE (2009)
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PLOS ONE (2009)
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SEMINARS IN ONCOLOGY (2009)
KSHV Reactivation from Latency Requires Pim-1 and Pim-3 Kinases to Inactivate the Latency-Associated Nuclear Antigen LANA
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PLOS PATHOGENS (2009)
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NATURE REVIEWS CANCER (2009)
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BIOCHEMICAL JOURNAL (2008)
Isoxazolo[3,4-b]quinoline-3,4(1H,9H)-diones as unique, potent and selective inhibitors for Pim-1 and Pim-2 kinases:: Chemistry, biological activities, and molecular modeling
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BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2008)
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BLOOD (2008)
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BLOOD (2008)
IL-3 induces a Pim1-dependent antiapoptotic pathway in primary human basophils
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BLOOD (2008)
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CANCER CELL (2008)
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CANCER RESEARCH (2008)
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CELL CYCLE (2008)
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JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Elevated levels of oncogenic protein kinase pim-1 induce the p53 pathway in cultured cells and correlate with increased mdm2 in mantle cell lymphoma
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JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
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MOLECULAR AND CELLULAR BIOLOGY (2008)
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MOLECULAR CANCER RESEARCH (2008)
Ki67 and PIM1 expression predict outcome in mantle cell lymphoma treated with high dose therapy, stem cell transplantation and rituximab: a Cancer and Leukemia Group B 59909 correlative science study
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LEUKEMIA & LYMPHOMA (2008)
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NATURE GENETICS (2008)
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ONCOGENE (2008)
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ONCOGENE (2008)
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JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY (2008)
Pim-1 and Pim-2 kinases are required for efficient pre-B-cell transformation by v-Abl oncogene
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BLOOD (2008)
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ONCOGENE (2008)
Pim2 complements Flt3 wild-type receptor in hematopoietic progenitor cell transformation
S. Agrawal et al.
LEUKEMIA (2008)
A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Pim-1 regulates cardiomyocyte survival downstream of Akt
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NATURE MEDICINE (2007)
Comparative molecular field analysis of flavonoid inhibitors of the PIM-1 kinase
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BIOORGANIC & MEDICINAL CHEMISTRY (2007)
Negative regulation of Pim-1 protein kinase levels by the B56β subunit of PP2A
J. Ma et al.
ONCOGENE (2007)
PIM1-dependent phosphorylation of histone H3 at serine 10 is required for MYC-dependent transcriptional activation and oncogenic transformation
Alessio Zippo et al.
NATURE CELL BIOLOGY (2007)
Structural analysis identifies imidazo[1,2-b]Pyridazines as PIM kinase inhibitors with In vitro antileukemic activity
Vanda Pogacic et al.
CANCER RESEARCH (2007)
PO2-dependent differential regulation of multidrug resistance 1 gene expression by the c-jun NH2-terminal Kinase pathway
Min Liu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Evidence that the Pim1 kinase gene is a direct target of HOXA9
Yu-Long Hu et al.
BLOOD (2007)
Hypoxia signalling controls metabolic demand
M. Christiane Brahimi-Horn et al.
CURRENT OPINION IN CELL BIOLOGY (2007)
Identification and structure-activity relationships of substituted pyridones as inhibitors of Pim-1 kinase
I. Wayne Cheney et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2007)
CXCR4 is a prognostic marker in acute myelogenous leukemia
Anke C. Spoo et al.
BLOOD (2007)
Self-renewal of murine embryonic stem cells is supported by the serine/threonine kinases pim-1 and pim-3
Irene Aksoy et al.
STEM CELLS (2007)
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John M. Busillo et al.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2007)
Characterization of a potent and selective small-molecule inhibitor of the PIM1 kinase
Sheldon Holder et al.
MOLECULAR CANCER THERAPEUTICS (2007)
Ruthenium half-sandwich complexes as protein kinase inhibitors:: An N-succinimidyl ester for rapid derivatizations of the cyclopentadienyl moiety
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ORGANIC LETTERS (2006)
Gene expression signatures separate B-cell chronic lymphocytic leukaemia prognostic subgroups defined by ZAP-70 and CD38 expression status
A. Huettmann et al.
LEUKEMIA (2006)
KSHV encoded LANA upregulates Pim-1 and is a substrate for its kinase activity
Bharat G. Bajaj et al.
VIROLOGY (2006)
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Leslie A. Gapter et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2006)
Pim-3, a proto-oncogene with serine/threonine kinase activity, is aberrantly expressed in human pancreatic cancer and phosphorylates Bad to block Bad-mediated apoptosis in human pancreatic cancer cell lines
Ying-Yi Li et al.
CANCER RESEARCH (2006)
Targeting PIM kinases impairs survival of hematopoietic cells transformed by kinase inhibitor-sensitive and kinase inhibitor-resistant forms of Fms-like tyrosine kinase 3 and BCR/ABL
M Adam et al.
CANCER RESEARCH (2006)
Targeting multidrug resistance in cancer
G Szakács et al.
NATURE REVIEWS DRUG DISCOVERY (2006)
Pim kinases phosphorylate multiple sites on Bad and promote 14-3-3 binding and dissociation from Bcl-XL
A Macdonald et al.
BMC CELL BIOLOGY (2006)
Structure and substrate specificity of the Pim-1 kinase
AN Bullock et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Structural basis of inhibitor specificity of the human protooncogene proviral insertion site in Moloney murine leukemia virus (PIM-1) kinase
AN Bullock et al.
JOURNAL OF MEDICINAL CHEMISTRY (2005)
The survival kinases Akt and Pim as potential pharmacological targets
R Amaravadi et al.
JOURNAL OF CLINICAL INVESTIGATION (2005)
Microarray-based classification of diffuse large B-cell lymphoma
CB Poulsen et al.
EUROPEAN JOURNAL OF HAEMATOLOGY (2005)
Pim and Akt oncogenes are independent regulators of hematopoietic cell growth and survival
PS Hammerman et al.
BLOOD (2005)
Crystal structures of proto-oncogene kinase pim1: A target of aberrant somatic hypermutations in diffuse large cell lymphoma
A Kumar et al.
JOURNAL OF MOLECULAR BIOLOGY (2005)
Pim-1 ligand-bound structures reveal the mechanism of serine/threonine kinase inhibition by LY294002
MD Jacobs et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
The serine/threonine kinase pim-1
M Bachmann et al.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2005)
Aberrant expression of serine/threonine kinase Pim-3 in hepatocellular carcinoma development and its role in the proliferation of human hepatoma cell lines
C Fujii et al.
INTERNATIONAL JOURNAL OF CANCER (2005)
Pim kinases are upregulated during Epstein-Barr virus infection and enhance EBNA2 activity
EM Rainio et al.
VIROLOGY (2005)
Structural basis of constitutive activity and a unique nucleotide binding mode of human PIM-1 kinase
KC Qian et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Pim-1 is up-regulated by constitutively activated FLT3 and plays a role in FLT3-mediated cell survival
KT Kim et al.
BLOOD (2005)
The Pim kinases control rapamycin-resistant T cell survival and activation
CJ Fox et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2005)
Increased expression of the hPim-2 gene in human chronic lymphocytic leukemia and non-Hodgkin lymphoma
AM Cohen et al.
LEUKEMIA & LYMPHOMA (2004)
Combination of rapamycin and protein tyrosine kinase (PTK) inhibitors for the treatment of leukemias caused by oncogenic PTKs
MG Mohi et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Randomized phase II study of multiple dose levels of CCI-779, a novel mammalian target of rapamycin kinase inhibitor, in patients with advanced refractory renal cell carcinoma
MB Atkins et al.
JOURNAL OF CLINICAL ONCOLOGY (2004)
Mammalian target of rapamycin inhibition as therapy for hematologic malignancies
A Panwalkar et al.
CANCER (2004)
Growth and survival mechanisms associated with perineural invasion in prostate cancer
GE Ayala et al.
CANCER RESEARCH (2004)
Role of pim-1 in smooth muscle cell proliferation
N Katakami et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Pim-1 kinase promotes inactivation of the pro-apoptotic bad protein by phosphorylating it on the Ser112 gatekeeper site
TLT Aho et al.
FEBS LETTERS (2004)
Mice deficient for all PIM kinases display reduced body size and impaired responses to hematopoietic growth factors
H Mikkers et al.
MOLECULAR AND CELLULAR BIOLOGY (2004)
Lymphocyte transformation by Pim-2 is dependent on nuclear factor-κB activation
PS Hammerman et al.
CANCER RESEARCH (2004)
The oncogenic serine/threonine kinase Pim-1 phosphorylates and inhibits the activity of Cdc25C-associated kinase 1 (C-TAK1) -: A novel role for Pim-1 at the G2/M cell cycle checkpoint
M Bachmann et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Identification of Flk-1 target genes in vasculogenesis: Pim-1 is required for endothelial and mural cell differentiation in vitro
A Zippo et al.
BLOOD (2004)
Pim-1 kinase inhibits STAT5-dependent transcription via its interactions with SOCS1 and SOCS3
KJ Peltola et al.
BLOOD (2004)
The PIM-2 kinase phosphorylates BAD on serine 112 and reverses BAD-induced cell death
B Yan et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Role of PI3K/AKT/mTOR signaling in the cell cycle progression of human prostate cancer
N Gao et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2003)
Aberrant somatic hypermutation in multiple subtypes of AIDS-associated non-Hodgkin lymphoma
G Gaidano et al.
BLOOD (2003)
BAD and glucokinase reside in a mitochondrial complex that integrates glycolysis and apoptosis
NN Danial et al.
NATURE (2003)
A gene expression-based method to diagnose clinically distinct subgroups of diffuse large B cell lymphoma
G Wright et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
The serine/threonine kinase Pim-2 is a transcriptionally regulated apoptotic inhibitor
CJ Fox et al.
GENES & DEVELOPMENT (2003)
PIM3 proto-oncogene kinase is a common transcriptional target of divergent EWS/IETS oncoproteins
B Deneen et al.
MOLECULAR AND CELLULAR BIOLOGY (2003)
Suppression of myeloid transcription factors and induction of STAT response genes by AML-specific Flt3 mutations
M Mizuki et al.
BLOOD (2003)
Protein phosphatase 2A regulates the stability of pim protein kinases
JA Losman et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Phosphorylation of the cell cycle inhibitor p21Cip1/WAF1 by Pim-1 kinase
ZP Wang et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2002)
High-throughput retroviral tagging to identify components of specific signaling pathways in cancer
H Mikkers et al.
NATURE GENETICS (2002)
Akt-dependent phosphorylation specifically regulates Cot induction of NF-κB-dependent transcription
LP Kane et al.
MOLECULAR AND CELLULAR BIOLOGY (2002)
Pim-1 associates with protein complexes necessary for mitosis
N Bhattacharya et al.
CHROMOSOMA (2002)
Akt maintains cell size and survival by increasing mTOR-dependent nutrient uptake
AL Edinger et al.
MOLECULAR BIOLOGY OF THE CELL (2002)
Complementary functions of the antiapoptotic protein A1 and serine/threonine kinase pim-1 in the BCR/ABL-mediated leukemogenesis
M Nieborowska-Skorska et al.
BLOOD (2002)
Pim serine/threonine kinases regulate the stability of Socs-1 protein
XP Chen et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
Pim-1 translocates sorting nexin 6/TRAF4-associated factor 2 from cytoplasm to nucleus
Y Ishibashi et al.
FEBS LETTERS (2001)
Delineation of prognostic biomarkers in prostate cancer
SM Dhanasekaran et al.
NATURE (2001)
Hypermutation of multiple proto-oncogenes in B-cell diffuse large-cell lymphomas
L Pasqualucci et al.
NATURE (2001)
Novel NEMO/IκB kinase and NF-κB target genes at the pre-B to immature B cell transition
J Li et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Regulation of Pim-1 by Hsp90
K Mizuno et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2001)
PAP-1, a novel target protein of phosphorylation by Pim-1 kinase
H Maita et al.
EUROPEAN JOURNAL OF BIOCHEMISTRY (2000)
Pim-1 kinase protects hematopoietic FDC cells from genotoxin-induced death
TJ Pircher et al.
ONCOGENE (2000)
Identification of heterochromatin protein 1 (HP1) as a phosphorylation target by Pim-1 kinase and the effect of phosphorylation on the transcriptional repression function of HP1
N Koike et al.
FEBS LETTERS (2000)