Related references
Note: Only part of the references are listed.Discovery of a novel protein kinase B inhibitor by structure-based virtual screening
Jose L. Medina-Franco et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2009)
Role of the small GTPase Rap1 for integrin activity regulation in endothelial cells and angiogenesis
Guillaume Carmona et al.
BLOOD (2009)
A functional genomics approach reveals novel quantitative trait loci associated with platelet signaling pathways
Chris I. Jones et al.
BLOOD (2009)
Genetic evidence for a predominant role of PI3Kβ catalytic activity in ITAM- and integrin-mediated signaling in platelets
Ilaria Canobbio et al.
BLOOD (2009)
A novel variant on chromosome 7q22.3 associated with mean platelet volume, counts, and function
Nicole Soranzo et al.
BLOOD (2009)
PIKKing on PKB: regulation of PKB activity by phosphorylation
Lana Bozulic et al.
CURRENT OPINION IN CELL BIOLOGY (2009)
Novel inhibitors of the PI3K family
Amancio Carnero
EXPERT OPINION ON INVESTIGATIONAL DRUGS (2009)
Role of Phosphoinositide 3-Kinase β in Glycoprotein VI-mediated Akt Activation in Platelets
Soochong Kim et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Insulin/IGF-1 hybrid receptor expression on human platelets: consequences for the effect of insulin on platelet function
R. W. Hunter et al.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2009)
Irreversible Platelet Activation Requires Protease-Activated Receptor 1-Mediated Signaling to Phosphatidylinositol Phosphates
Michael Holinstat et al.
MOLECULAR PHARMACOLOGY (2009)
The endogenous inhibitor of Akt, CTMP, is critical to ischemia-induced neuronal death
Takahiro Miyawaki et al.
NATURE NEUROSCIENCE (2009)
TRIB3 r84 variant is associated with impaired insulin-mediated nitric oxide production in human endothelial cells
Francesco Andreozzi et al.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2008)
Platelet protein interactions - Map, signaling components, and phosphorylation groundstate
Marcus Dittrich et al.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2008)
GSK3 beta is a negative regulator of platelet function and thrombosis
Dongjun Li et al.
BLOOD (2008)
The role of Akt in the signaling pathway of the, glycoprotein Ib-IX-induced platelet activation
Hong Yin et al.
BLOOD (2008)
PI(3,4,5)P3 and PI(3,4)P2 levels correlate with PKB/akt phosphorylation at Thr308 and Ser473, respectively;: PI(3,4)P2 levels determine PKB activity
Kewei Ma et al.
CELLULAR SIGNALLING (2008)
Advantages of a selective β-isofonn phosphoinositide 3-kinase antagonist, an anti-thrombotic agent devoid of other cardiovascular actions in the rat
Sharelle A. Sturgeon et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2008)
VEGF stimulation of mitochondrial biogenesis: requirement of AKT3 kinase
Gary L. Wright et al.
FASEB JOURNAL (2008)
Signaling-mediated Functional Activation of Inducible Nitric-oxide Synthase and Its Role in Stimulating Platelet Activation
Jasna A. Marjanovic et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Regulation of Akt/PKB activity by P21-activated kinase in cardiomyocytes
Kai Mao et al.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2008)
The PKB inhibitor Akti-1/2 potentiates PAR-1-mediated platelet function independently of its ability to block PKB
R. W. Hunter et al.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2008)
Globular adiponectin increases cGMP formation in blood platelets independently of nitric oxide
R. Riba et al.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2008)
NO-synthase-/NO-independent regulation of human and murine platelet soluble guanylyl cyclase activity
S. Gambaryan et al.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2008)
Nitric oxide specifically inhibits integrin-mediated platelet adhesion and spreading on collagen
W. Roberts et al.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2008)
PKBα/Akt1 acts downstream of DNA-PK in the DNA double-strand break response and promotes survival
Lana Bozulic et al.
MOLECULAR CELL (2008)
EPAC and PKA allow cAMP dual control over DNA-PK nuclear translocation
Elaine Huston et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Insulin-like growth factor-1 potentiates platelet activation via the IRS/PI3Kα pathway
Ingeborg Hers
BLOOD (2007)
Insulin-like growth factor-1 regulates platelet activation through PI3-Kα isoform
Soochong Kim et al.
BLOOD (2007)
Protease-activated receptor-induced Akt activation -: regulation and possible function
J. C. Resendiz et al.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2007)
Identification of a unique co-operative phosphoinositide 3-kinase signaling mechanism regulating integrin αIIbβ3 adhesive function in platelets
Simone M. Schoenwaelder et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Thrombin regulates intracellular cyclic AMP concentration in human platelets through phosphorylation/activation of phosphodiesterase 3A
Wei Zhang et al.
BLOOD (2007)
Mapping of deletion and translocation breakpoints in 1q44 implicates the serine/threonine kinase AKT3 in postnatal microcephaly and agenesis of the corpus callosum
Elena Boland et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2007)
AKT/PKB signaling: Navigating downstream
Brendan D. Manning et al.
CELL (2007)
Deficiency of Src homology 2 domain-containing inositol 5-phosphatase 1 affects platelet responses and thrombus growth
Sonia Severin et al.
JOURNAL OF CLINICAL INVESTIGATION (2007)
Threonine phosphorylation of integrin β3 in calyculin A-treated platelets is selectively sensitive to 5′-iodotubercidin
Kenneth M. Lerea et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2007)
Life with a single isoform of Akt: Mice lacking Akt2 and Akt3 are viable but display impaired glucose homeostasis and growth deficiencies
Bettina Dummler et al.
MOLECULAR AND CELLULAR BIOLOGY (2006)
Continuous signaling via PI3K isoforms β and γ is required for platelet ADP receptor function in dynamic thrombus stabilization
Judith M. E. M. Cosemans et al.
BLOOD (2006)
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism
Jeffrey A. Engelman et al.
NATURE REVIEWS GENETICS (2006)
Soluble CD40L levels are regulated by the -3459 A>G polymorphism and predict myocardial infarction and the efficacy of antithrombotic treatment in non-ST elevation acute coronary syndrome
Anders Malarstig et al.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2006)
A phosphoinositide 3-kinase-AKT-nitric oxide-cGMP signaling pathway in stimulating platelet secretion and aggregation
Aleksandra Stojanovic et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Relative contribution of G-protein-coupled pathways to protease-activated receptor-mediated Akt phosphorylation in platelets
S Kim et al.
BLOOD (2006)
mTOR•RICTOR is the Ser473 kinase for Akt/protein kinase B in 3T3-L1 adipocytes
RC Hresko et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Stimulatory roles of nitric-oxide synthase 3 and guanylyl cyclase in platelet activation
JA Marjanovic et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
CD40 ligand influences platelet release of reactive oxygen intermediates
S Chakrabarti et al.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2005)
Glucose uptake via glucose transporter 3 by human platelets is regulated by protein kinase B
IA Ferreira et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
The functional Q84R polymorphism of mammalian tribbles homolog TRB3 is associated with insulin resistance and related cardiovascular risk in Caucasians from Italy
S Prudente et al.
DIABETES (2005)
Akt1/protein kinase Bα is critical for ischemic and VEGF-mediated angiogenesis
E Ackah et al.
JOURNAL OF CLINICAL INVESTIGATION (2005)
Essential role of protein kinase Bγ (PKBγ/Akt3) in postnatal brain development but not in glucose homeostasis
O Tschopp et al.
DEVELOPMENT (2005)
The relative role of PLCβ and PI3Kγ in platelet activation
LR Lian et al.
BLOOD (2005)
PI 3-kinase p110β:: a new target for antithrombotic therapy
SP Jackson et al.
NATURE MEDICINE (2005)
Regulation of platelet granule exocytosis by S-nitrosylation
CN Morrell et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Role for Akt3/Protein kinase Bγ in attainment of normal brain size
RM Easton et al.
MOLECULAR AND CELLULAR BIOLOGY (2005)
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
DD Sarbassov et al.
SCIENCE (2005)
Structure, regulation and function of PKB/AKT - a major therapeutic target
M Hanada et al.
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS (2004)
Akt activation in platelets depends on Gi signaling pathways
S Kim et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Integrins: dynamic scaffolds for adhesion and signaling in platelets
SJ Shattil et al.
BLOOD (2004)
Impaired platelet responses to thrombin and collagen in AKT-1-deficient mice
JH Chen et al.
BLOOD (2004)
SHIP1 and Lyn kinase negatively regulate integrin αIIbβ3 signaling in platelets
MJ Maxwell et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Protein kinase C βII regulates Akt phosphorylation on Ser-473 in a cell type- and stimulus-specific fashion
Y Kawakami et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
A family with severe insulin resistance and diabetes due to a mutation in AKT2
S George et al.
SCIENCE (2004)
Deregulated Akt3 activity promotes development of malignant melanoma
JM Stahl et al.
CANCER RESEARCH (2004)
SH2-containing inositol 5-phosphatases 1 and 2 in blood platelets: their interactions and roles in the control of phosphatidylinositol 3,4,5-trisphosphate levels
S Giuriato et al.
BIOCHEMICAL JOURNAL (2003)
Regulation of glycogen synthase kinase 3 in human platelets: a possible role in platelet function?
FA Barry et al.
FEBS LETTERS (2003)
Two waves of platelet secretion induced by thromboxane A2 receptor and a critical role for phosphoinositide 3-kinases
ZY Li et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
A selective role for phosphatidylinositol 3,4,5-trisphosphate in the Gi-dependent activation of platelet Rap1B
P Lova et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Protease-activated receptors 1 and 4 do not stimulate Gi signaling pathways in the absence of secreted ADP and cause human platelet aggregation independently of Gi signaling
S Kim et al.
BLOOD (2002)
Akt1/PKBα is required for normal growth but dispensable for maintenance of glucose homeostasis in mice
H Cho et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKBβ)
H Cho et al.
SCIENCE (2001)
Mechanism of phosphorylation of protein kinase B/Akt by a constitutively active 3-phosphoinositide-dependent protein kinase-1
MJ Wick et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Threonine phosphorylation of the β3 integrin cytoplasmic tail, at a site recognized by PDK1 and Akt/PKB in vitro, regulates Shc binding
RI Kirk et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)