Journal
EXPERT REVIEW OF HEMATOLOGY
Volume 3, Issue 1, Pages 81-91Publisher
EXPERT REVIEWS
DOI: 10.1586/EHM.09.75
Keywords
Akt; glycogen synthase kinase3; PI3K; platelet; thrombosis
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Funding
- NIH [R01HL081241]
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Akt is a Ser-Thr kinase with pleiotropic effects on cell survival, growth and metabolism. Recent evidence from gene-deletion studies in mice, and analysis of human platelets treated with Akt inhibitors, suggest that Akt regulates platelet activation, with potential consequences for thrombosis. Akt activation is regulated by the level of phosphoinositide 3-phosphates, and proteins that regulate concentrations of this lipid also regulate Akt activation and platelet function. Although the effectors through which Akt contributes to platelet activation are not definitively known, several candidates are discussed, including endothelial nitric oxide synthase, glycogen synthase kinase 33, phosphodiesterase 3A and the integrin beta(3) tail. Selective inhibitors of Akt isoforms or of proteins that contribute to its activation, such as individual PI3K isoforms, may make attractive targets for antithrombotic therapy. This review summarizes the current literature describing Akt activity and its regulation in platelets, including speculation regarding the future of Akt or its regulatory pathways as targets for the development of antithrombotic therapies.
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