Journal
JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH
Volume 3, Issue 4, Pages 297-303Publisher
SPRINGER
DOI: 10.1007/s12265-010-9188-4
Keywords
Hypertrophy; Genetics; Genomics; Heart Failure
Funding
- Ministry of Education, Culture, Sports, Science, and Technology of Japan
- TAKEDA Science Foundation
- National Institutes of Health
- Leducq Foundation
- Howard Hughes Medical Institute
- Grants-in-Aid for Scientific Research [21590925] Funding Source: KAKEN
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Despite considerable progress in identifying and modifying risk factors that cause cardiovascular disease, heart failure has emerged as an important medical and socioeconomic problem. Hypertrophic remodeling, a common response to many cardiovascular disorders, increases the risk of heart failure. Discovery of the genetic basis of hypertrophic cardiomyopathy has allowed consideration of whether these genes also contribute to pathologic remodeling that occurs in the context of common acquired cardiovascular disorders. Evidence supporting a shared etiology has emerged from the recent identification of sarcomere protein mutations and sequence variants in community-based populations with hypertrophy and heart failure. These findings imply that harnessing genetic testing for hypertrophic mutations may help define patients at risk for heart failure. In the future, mechanistic insights into hypertrophic remodeling, combined with strategies to prevent this pathology, are expected to reduce the burden of heart failure.
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