Journal
JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH
Volume 4, Issue 2, Pages 177-181Publisher
SPRINGER
DOI: 10.1007/s12265-010-9253-z
Keywords
Catheter; Intramyocardial delivery; Intravenous; Intracoronary; Coronary sinus
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The field of myocardial regeneration utilizing novel cell-based therapies, gene transfer, and growth factors may prove to play an important role in the future management of ischemic heart disease and cardiomyopathy. Phases I and II clinical trials have been published for a variety of biologics utilizing four methods of delivery: systemic infusion, intracoronary infusion, transvenous coronary sinus, and intramyocardial. This review discusses the advantages and disadvantages of the delivery approaches above.
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