Journal
CELL DEATH & DISEASE
Volume 4, Issue -, Pages -Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/cddis.2013.253
Keywords
reactive oxygen species; megakaryocytopoiesis; platelet activation; microenvironment; regulation
Categories
Funding
- National Natural Science Fund of China [31071025]
- National '863' High-tech Development Plan [2007AA02Z152]
- Special Fund from PLA [BSW11J009]
- Key Basic Research and Development Plan of China [2012CB518103]
- Funds of Key Laboratory of Trauma, Burn, and Combined Injury [SKLZZ201115, SKLZZ201016, SKLKF200911]
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Platelets have an important role in the body because of their manifold functions in haemostasis, thrombosis, and inflammation. Platelets are produced by megakaryocytes (MKs) that are differentiated from haematopoietic stem cells via several consecutive stages, including MK lineage commitment, MK progenitor proliferation, MK differentiation and maturation, cell apoptosis, and platelet release. During differentiation, the cells migrate from the osteoblastic niche to the vascular niche in the bone marrow, which is accompanied by reactive oxygen species (ROS)-dependent oxidation state changes in the microenvironment, suggesting that ROS can distinctly influence platelet generation and function in a microenvironment-dependent manner. The objective of this review is to reveal the role of ROS in regulating MK proliferation, differentiation, maturation, and platelet activation, thereby providing new insight into the mechanism of platelet generation, which may lead to the development of new therapeutic agents for thrombocytopenia and/or thrombosis.
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