Journal
CELL DEATH & DISEASE
Volume 4, Issue -, Pages -Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/cddis.2013.486
Keywords
neuronal progenitor cell; PDGF-BB; miR-9; MCPIP1; neurogenesis
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Funding
- National Institutes of Health [MH-068212, DA020392, DA023397, DA024442]
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Highly conserved microRNA-9 (miR-9) has a critical role in various cellular processes including neurogenesis. However, its regulation by neurotropins that are known to mediate neurogenesis remains poorly defined, In this study, we identify plateletderived growth factor-BB (PDGF-BB)-mediated upregulation of miR-9, which in turn downregulates its target gene nionocyte chemotactic protein-induced protein 1 (MCPIP1), as a key player in modulating proliferation, neuronal differentiation as well as migration of neuronal progenitor cells (NPCs). Results indicate that rAR-9-mediated NPC proliferation and neuronal differentiation involves signaling via the nuclear factor-kappa B (NF-KB) and cAMP response element-binding protein (CREB) pathways, and that NPC migration involves CREB but not the NF-KB signaling. These findings thus suggest that miR-9-mediated downregulation of MCPIP1 acts as a molecular switch regulation of neurogenesis.
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