Journal
CELL DEATH & DISEASE
Volume 3, Issue -, Pages -Publisher
SPRINGERNATURE
DOI: 10.1038/cddis.2012.177
Keywords
tunneling nanotube; direction; S100A4; caspase-3; cell death
Categories
Funding
- National Program of Basic Research
- Ministry of Science and Technology of China [2009CB941301]
- National Science Foundation of China (NSFC) [91132718]
- NSFC Major Research Grant (NSFC) [91132306]
- General Funds (NSFC) [30970942]
- National Basic Research Program of China (973 program) [2010CB529605]
- Instrument Developing Project of the Chinese Academy of Sciences [2010019]
- 'Hundred Talents Program' of Chinese Academy of Science
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A tunneling nanotube (TNT) is a newly discovered structure involved in cell-cell communication and is found in various types of cells. Here we identify S100A4 as an extracellular molecule and describe its role in attracting the growth direction of TNTs. Together with its putative receptor, receptor for advanced glycation end product, we demonstrate their involvement in TNT direction guidance. Our results further suggest a mechanism for direction guidance of TNTs. In TNT-initiating cells, p53 activates caspase-3, which leads to S100A4 cleavage and its subsequent decrease in cellular concentration. The decrease in cellular S100A4 induces the formation of a gradient of S100A4, from a low concentration in initiating cells toward a high concentration in target cells. This concentration gradient of S100A4 induces direction guidance for TNTs. Cell Death and Disease (2012) 3, e438; doi:10.1038/cddis.2012.177; published online 6 December 2012
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