Journal
CELL DEATH & DISEASE
Volume 2, Issue -, Pages -Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/cddis.2011.77
Keywords
hERG; K+ channel; cell proliferation; apoptosis; anticancer therapy
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Funding
- ADUMED foundation
- German Heart Foundation/German Foundation of Heart Research
- Max-Planck-Society
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The human ether-a-go-go-related gene potassium channel (hERG, Kv11.1, KCNH2) has an essential role in cardiac action potential repolarization. Electrical dysfunction of the voltage-sensitive ion channel is associated with potentially lethal ventricular arrhythmias in humans. hERG K+ channels are also expressed in a variety of cancer cells where they control cell proliferation and apoptosis. In this review, we discuss molecular mechanisms of hERG-associated cell cycle regulation and cell death. In addition, the significance of hERG K+ channels as future drug target in anticancer therapy is highlighted. Cell Death and Disease (2011) 2, e193; doi: 10.1038/cddis.2011.77; published online 18 August 2011
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