Journal
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY
Volume 6, Issue 9, Pages -Publisher
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/cshperspect.a016840
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Funding
- MRC programme grant [G0900113]
- Wellcome Trust Principal Research Fellowship [075880]
- Wellcome Trust [097024]
- Wellcome Trust Strategic Award [100140]
- MRC [G0900113] Funding Source: UKRI
- Medical Research Council [G0900113] Funding Source: researchfish
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Lysosomes were once considered the end point of endocytosis, simply used for macromolecule degradation. They are now recognized to be dynamic organelles, able to fuse with a variety of targets and to be re-formed after fusion events. They are also now known to be the site of nutrient sensing and signaling to the cell nucleus. In addition, lysosomes are secretory organelles, with specialized machinery for regulated secretion of proteins in some cell types. The biogenesis of lysosomes and lysosome-related organelles is discussed, taking into account their dynamic nature and multiple roles.
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