Journal
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY
Volume 6, Issue 10, Pages -Publisher
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/cshperspect.a016857
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Funding
- Netherlands Organization for Scientific Research (NWO) (VICI) [918.56.611]
- National Institutes of Health [R01 EY015625]
- Institute Curie, CNRS
- Foundation ARC pour la recherche sur le cancer [SL220100601359]
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Live-cell imaging reveals the endolysosomal system as a complex and highly dynamic network of interacting compartments. Distinct types of endosomes are discerned by kinetic, molecular, and morphological criteria. Although none of these criteria, or combinations thereof, can capture the full complexity of the endolysosomal system, they are extremely useful for experimental purposes. Some membrane domain specializations and specific morphological characteristics can only be seen by ultrastructural analysis after preparation for electron microscopy (EM). Immuno-EM allows a further discrimination of seemingly identical compartments by their molecular makeup. In this review we provide an overview of the ultrastructural characteristics and membrane organization of endosomal compartments, along with their organizing machineries.
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