Journal
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY
Volume 6, Issue 2, Pages -Publisher
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/cshperspect.a020735
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Funding
- National Science Foundation (NSF) [MCB-0845062]
- NSF [0954836]
- New Mexico Spatiotemporal Modeling Center (National Institutes of Health) [P50GM085273]
- Direct For Mathematical & Physical Scien
- Division Of Physics [0954836] Funding Source: National Science Foundation
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Signal transduction is regulated by protein-protein interactions. In the case of the ErbB family of receptor tyrosine kinases (RTKs), the precise nature of these interactions remains a topic of debate. In this review, we describe state-of-the-art imaging techniques that are providing new details into receptor dynamics, clustering, and interactions. We present the general principles of these techniques, their limitations, and the unique observations they provide about ErbB spatiotemporal organization.
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