Journal
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY
Volume 4, Issue 2, Pages -Publisher
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/cshperspect.a008342
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Funding
- Canadian Institutes of Health Research
- Muscular Dystrophy Association
- National Institutes of Health
- Howard Hughes Medical Institute
- Canadian Stem Cell Network
- Canada Research Chair Program
- Swiss National Science Foundation
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The genesis of skeletal muscle during embryonic development and postnatal life serves as a paradigm for stem and progenitor cell maintenance, lineage specification, and terminal differentiation. An elaborate interplay of extrinsic and intrinsic regulatory mechanisms controls myogenesis at all stages of development. Many aspects of adult myogenesis resemble or reiterate embryonic morphogenetic episodes, and related signaling mechanisms control the genetic networks that determine cell fate during these processes. An integrative view of all aspects of myogenesis is imperative for a comprehensive understanding of muscle formation. This article provides a holistic overview of the different stages and modes of myogenesis with an emphasis on the underlying signals, molecular switches, and genetic networks.
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