Journal
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY
Volume 4, Issue 9, Pages -Publisher
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/cshperspect.a011403
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Funding
- Canadian Institutes of Health Research
- Natural Sciences and Engineering Research Council of Canada
- Canadian Institute for Advanced Research
- Canada Research Chairs Program
- Canada Foundation for Innovation
- Genome Canada
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Viewed through the lens of the genome it contains, the mitochondrion is of unquestioned bacterial ancestry, originating from within the bacterial phylum alpha-Proteobacteria (Alphaproteobacteria). Accordingly, the endosymbiont hypothesis-the idea that the mitochondrion evolved from a bacterial progenitor via symbiosis within an essentially eukaryotic host cell-has assumed the status of a theory. Yet mitochondrial genome evolution has taken radically different pathways in diverse eukaryotic lineages, and the organelle itself is increasingly viewed as a genetic and functional mosaic, with the bulk of the mitochondrial proteome having an evolutionary origin outside Alphaproteobacteria. New data continue to reshape our views regarding mitochondrial evolution, particularly raising the question of whether the mitochondrion originated after the eukaryotic cell arose, as assumed in the classical endosymbiont hypothesis, or whether this organelle had its beginning at the same time as the cell containing it.
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