Journal
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY
Volume 3, Issue 7, Pages -Publisher
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/cshperspect.a004952
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Funding
- National Institutes of Health [GM33063, HL57345, F32DK085905]
- Fondation pour la Recherche Medicale
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Heparan sulfate proteoglycans are found at the cell surface and in the extracellular matrix, where they interact with a plethora of ligands. Over the last decade, new insights have emerged regarding the mechanism and biological significance of these interactions. Here, we discuss changing views on the specificity of protein-heparan sulfate binding and the activity of HSPGs as receptors and coreceptors. Although fewin number, heparan sulfate proteoglycans have profound effects at the cellular, tissue, and organismal level.
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