Journal
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY
Volume 3, Issue 5, Pages -Publisher
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/cshperspect.a005033
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Funding
- National Institute of General Medical Sciences (NIH) [U54GM64346]
- Nanotechnology Center for Mechanics in Regenerative Medicine [PN2 EY016586]
- Mario Negri Institute for Pharmacological Research - Weizmann Institute of Science
- Israel Science Foundation
- National Institute of Dental and Craniofacial Research
- National Institutes of Health
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Cell adhesions mediate important bidirectional interactions between cells and the extracellular matrix. They provide an interactive interface between the extracellular chemical and physical environment and the cellular scaffolding and signaling machinery. This dynamic, reciprocal regulation of intracellular processes and the matrix is mediated by membrane receptors such as the integrins, as well as many other components that comprise the adhesome. Adhesome constituents assemble themselves into different types of cell adhesion structures that vary in molecular complexity and change over time. These cell adhesions play crucial roles in cell migration, proliferation, and determination of cell fate.
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