Journal
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY
Volume 4, Issue 1, Pages -Publisher
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/cshperspect.a003541
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No community-accepted scientific methods are available today to guide studies on what role RNAplayed in the origin and early evolution of life on Earth. Further, a definition-theory for life is needed to develop hypotheses relating to the RNA First model for the origin of life. Four approaches are currently at various stages of development of such a definition-theory to guide these studies. These are (a) paleogenetics, in which inferences about the structure of past life are drawn from the structure of present life; (b) prebiotic chemistry, in which hypotheses with experimental support are sought that get RNA from organic and inorganic species possibly present on early Earth; (c) exploration, hoping to encounter life independent of terran life, which might contain RNA; and (d) synthetic biology, in which laboratories attempt to reproduce biological behavior with unnatural chemical systems.
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