Journal
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY
Volume 2, Issue 8, Pages -Publisher
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/cshperspect.a004085
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- Wellcome Trust
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Calcium signaling in neurons as in other cell types mediates changes in gene expression, cell growth, development, survival, and cell death. However, neuronal Ca2+ signaling processes have become adapted to modulate the function of other important pathways including axon outgrowth and changes in synaptic strength. Ca2+ plays a key role as the trigger for fast neurotransmitter release. The ubiquitous Ca2+ sensor calmodulin is involved in various aspects of neuronal regulation. The mechanisms by which changes in intracellular Ca2+ concentration in neurons can bring about such diverse responses has, however, become a topic of widespread interest that has recently focused on the roles of specialized neuronal Ca2+ sensors. In this article, we summarize synaptotagmins in neurotransmitter release, the neuronal roles of calmodulin, and the functional significance of the NCS and the CaBP/calneuron protein families of neuronal Ca2+ sensors.
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