Journal
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY
Volume 1, Issue 5, Pages -Publisher
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/cshperspect.a002998
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Funding
- Association pour la Recherche sur le Cancer (ARC)
- Fondation Schlumberger pour l'Education et la Recherche (FSER)
- CNRS
- ANR
- Fondation Recherche Medicale (equipe FRM)
- HFSP
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Epithelial cell-cell junctions are formed by apical adherens junctions (AJs), which are composed of cadherin adhesion molecules interacting in a dynamic way with the cortical actin cytoskeleton. Regulation of cell-cell junction stability and dynamics is crucial to maintain tissue integrity and allow tissue remodeling throughout development. Actin filament turnover and organization are tightly controlled together with myosin-II activity to produce mechanical forces that drive the assembly, maintenance, and remodeling of AJs. In this review, we will discuss these three distinct stages in the lifespan of cell-cell junctions, using several developmental contexts, which illustrate how mechanical forces are generated and transmitted at junctions, and how they impact on the integrity and the remodeling of cell-cell junctions.
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