Journal
CELL DIVISION
Volume 6, Issue -, Pages -Publisher
BIOMED CENTRAL LTD
DOI: 10.1186/1747-1028-6-21
Keywords
Wee1; Mus81/Eme1; Replication; Genomic integrity; Cell cycle; Cdk2
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Funding
- Spanish Ministry of Science and Innovation [SAF2010-22126, CONSOLIDER-Ingenio 2010 CDS2007-0015]
- FUNCIS [PI27/062]
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Maintenance of genomic integrity is essential for cell survival. Specifically, during DNA replication cells use a complex network of mechanisms that prevents genomic instability. Recently, we and others identified Wee1, a serine/threonine and tyrosine kinase, as a new modulator of the genomic stability during S phase. Loss of its activity causes a general DNA damage response activation and a decrease in replication fork speed. These effects are counteracted by the downregulation of the endonuclease complex Mus81-Eme1, showing a new link between this endonuclease and Wee1 during DNA replication. Here we discuss the function of Wee1 in genomic stability and its relationship with the Mus81-Eme1 complex.
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