Journal
JOURNAL OF MOLECULAR CELL BIOLOGY
Volume 6, Issue 1, Pages 64-74Publisher
OXFORD UNIV PRESS
DOI: 10.1093/jmcb/mjt051
Keywords
Wnt; glutamate; Alzheimers disease; synapses; dendritic spines; neuroprotection
Categories
Funding
- FONDECYT [1120156, 11110012]
- Basal Center of Excellence in Science and Technology [CONICYT-PFB12/2007]
Ask authors/readers for more resources
Wnts comprise a large family of proteins that have shown to be part of a signaling cascade that regulates several aspects of development including organogenesis, midbrain development as well as stem cell proliferation. Wnt signaling pathway plays different roles in the development of neuronal circuits and also in the adult brain, where it regulates synaptic transmission and plasticity. It has been also implicated in various diseases including cancer and neurodegenerative diseases, reflecting its relevance in fundamental biological processes. This review summarizes the progress about Wnts function in mature nervous system with a focus on Alzheimers disease (AD). We discuss the prospects of modulating canonical and non-canonical Wnt signaling as a strategy for neuroprotection. This will include the potential of Wnts to: (i) act as potent regulators of hippocampal synapses and impact in learning and memory; (ii) regulate adult neurogenesis; and finally (iii) control AD pathogenesis.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available