Journal
JOURNAL OF MOLECULAR CELL BIOLOGY
Volume 3, Issue 1, Pages 1-3Publisher
OXFORD UNIV PRESS
DOI: 10.1093/jmcb/mjq057
Keywords
-
Categories
Funding
- NCI NIH HHS [R01 CA156706] Funding Source: Medline
Ask authors/readers for more resources
Genomic instability refers to an increased tendency of alterations in the genome during the life cycle of cells. It is a major driving force for tumorigenesis. During a cell division, genomic instability is minimized by four major mechanisms: high-fidelity DNA replication in S-phase, precise chromosome segregation in mitosis, error free repair of sporadic DNA damage, and a coordinated cell cycle progression. This introduction summarizes the major molecular processes that contribute to these mechanisms in the context of prevention of genomic instability and tumorigenesis.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available