Journal
JOURNAL OF MOLECULAR CELL BIOLOGY
Volume 3, Issue 5, Pages 276-282Publisher
OXFORD UNIV PRESS
DOI: 10.1093/jmcb/mjr013
Keywords
FoxO; post-translational modification; cancer
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Funding
- Ministry of Science and Technology of China [2011CB910100]
- National Natural Science Foundation of China [30900722, 31070691]
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The functions of the FoxO family proteins, in particular their transcriptional activities, are modulated by post-translational modifications (PTMs), including phosphorylation, acetylation, ubiquitination, methylation and glycosylation. These PTMs occur in response to different cellular stresses, which in turn regulate the subcellular localization of FoxO family proteins, as well as their half-life, DNA binding, transcriptional activity and ability to interact with other cellular proteins. In this review, we summarize the role of PTMs of FoxO family proteins in linking their biological and functional relevance with various diseases.
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