Journal
JOURNAL OF MOLECULAR CELL BIOLOGY
Volume 1, Issue 1, Pages 8-10Publisher
OXFORD UNIV PRESS
DOI: 10.1093/jmcb/mjp007
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Some lethal stimuli can induce either apoptosis or necrosis, depending on the cell type and/or experimental setting. Until recently, the molecular bases of this phenomenon were largely unknown. Now, two members of the receptor-interacting serine-threonine kinase (RIP) family, RIP1 and RIP3, have been demonstrated to control the switch between apoptotic and necrotic cell death. Some mechanistic details, however, remain controversial.
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