Journal
HPB
Volume 14, Issue 3, Pages 177-+Publisher
ELSEVIER SCI LTD
DOI: 10.1111/j.1477-2574.2011.00423.x
Keywords
Helicobacter pylori; H. bilis; cagA; hepatobiliary diseases; cholangiocarcinoma; inflammation; proliferation
Categories
Funding
- Commission on Higher Education, Thailand
- Khon Kaen University
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Objectives: To investigate whether Helicobacter spp. infection and the cagA of H. pylori are associated with hepatobiliary pathology, specifically biliary inflammation, cell proliferation and cholangiocarcinoma (CCA). Methods: Helicobacter species including H. pylori, H. bilis and H. hepaticus were detected in the specimens using the polymerase chain reaction (PCR). Biliary inflammation of the liver and gallbladders was semi- quantitatively graded on hematoxylin and eosin (H& E)- stained slides. Biliary proliferation was evaluated by immunohistochemistry using the Ki- 67- labelling index. Results: Helicobacter pylori was found in 66.7%, 41.5% and 25.0% of the patients in the CCA, cholelithiasis and control groups (P < 0.05), respectively. By comparison, H. bilis was found in 14.9% and 9.4% of the patients with CCA and cholelithiasis, respectively (P > 0.05), and was absent in the control group. The cagA gene of H. pylori was detected in 36.2% and 9.1% of the patients with CCA and cholelithiasis, respectively (P < 0.05). Among patients with CCA, cell inflammation and proliferation in the liver and gallbladder were significantly higher among those DNA H. pylori positive than negative. Conclusions: The present findings suggest that H. pylori, especially the cagA- positive strains, may be involved in the pathogenesis of hepatobiliary diseases, especially CCA through enhanced biliary cell inflammation and proliferation.
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