Journal
JOURNAL OF FUNCTIONAL FOODS
Volume 10, Issue -, Pages 169-177Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jff.2014.06.007
Keywords
Ginseng; High hydrostatic pressure extract; Hot water extract; Anti-obesity; Anti-inflammation; Rat
Categories
Funding
- Food High Pressure Technology Development Project
- Korea Food Research Institute [202007-03-03-WT011]
- National Research Foundation of Korea (NRF) - Korean Government (MOE) [2013R1A1A2009522]
- National Research Foundation of Korea [2013R1A1A2009522] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Obesity is associated with a state of chronic, low-grade inflammation. High hydrostatic pressure, a non-thermal food processing technique, increases extraction efficiency without destroying heat-sensitive bioactive constituents. This study investigated effects of high hydrostatic pressure extract of ginseng (PEG) and hot water extract of ginseng (WEG) on obesity and inflammation in rats fed a high-fat diet. The contents of total phenolics, saponins and acidic polysaccharides of PEG were higher than those of WEG. PEG reduced the body weight and white adipose tissue mass. PEG increased faecal triacylglycerol, whereas WEG did not. PEG reduced mRNA levels of adipogenic genes such as PPAR gamma and aP2. The mRNA levels of proinflammatory genes such as TNF-alpha, IL-6 and MCP-1 were down-regulated by the PEG, whereas WEG did not. These results suggest PEG may have more beneficial effects on obesity and inflammation than WEG, partially mediated by increase of faecal triacylglycerol and regulation of gene expression. (C) 2014 Elsevier Ltd. All rights reserved.
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