Journal
JOURNAL OF FUNCTIONAL FOODS
Volume 10, Issue -, Pages 318-326Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jff.2014.06.014
Keywords
Lactobacillus rhamnosus CCFM0528; Glucose tolerance; Type 2 diabetic; Blood glucose
Categories
Funding
- National High Technology Research and Development Program of China (863 Program) [2011AA100901, 2011AA100902, 2013BAD18B01]
- National Natural Science Foundation of China [31200691]
- Key Program of the National Natural Science Foundation of China [20836003]
- National Basic Research Program of China (973 Program) [2012CB720802]
- key projects in the National Science and Technology Pillar Program during the 12th Five-Year Plan [2012BAD12B08, 2012BAD28807]
- 111 project [B07029]
- Fundamental Research Funds for the Central Universities [JUSRP111A31]
- Priority Academic Program Development of Jiangsu Higher Education Institutions
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In this study, the effects of Lactobacillus rhamnosus CCFM0528, a new probiotic strain isolated by our laboratory glucose tolerance, hyperglycemia and cytokine secretion in high-fat-fed, streptozotocin-induced type 2 diabetic mice were studied. The results indicate that L. rhamnosus CCFM0528 significantly decreased fasting and postprandial 2-h blood glucose, glycosylated hemoglobin (HbA1c), endotoxin, tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and interleukin-8 (IL-8) levels compared with the control group (P < 0.05). However, the values for insulin, glycogen, interleuldn-4 (IL-4), and interleukin-10 (IL-10) were effectively increased at 13 weeks (P < 0.05). The cytokine gene expressions in spleen were regulated, and the islet cells were protected by L. rhamnosus CCFM0528. These findings demonstrated the antidiabetic effect of L. rhamnosus CCFM0528 on mice with type 2 diabetic induced by a high-fat diet and streptozotocin. Our study suggested that L. rhamnosus CCFM0528 may be a promising therapeutic agent in treating type 2 diabetes. (C) 2014 Elsevier Ltd. All rights reserved.
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