Journal
JOURNAL OF FUNCTIONAL FOODS
Volume 6, Issue -, Pages 339-347Publisher
ELSEVIER
DOI: 10.1016/j.jff.2013.10.025
Keywords
Alcohol; Ecklonia cava; Oxidative stress; Hepato-protective effect; Zebrafish
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Funding
- National Research Foundation of Korea (NRF)
- Ministry of Education [2013-0611]
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In the present study, the protective effects of polyphenol extract from Ecklonia cava (EPE) against ethanol-induced cell damage and oxidative stress were investigated in vitro and in vivo. E. cava was selected among twenty marine brown algae due to less cytotoxicity and higher cell viability against the ethanol-induced cell damage. The EPE extract showed the protective effect against the ethanol-mediated apoptosis, which was investigated via nuclear staining with Hoechst 33342 and flow cytometry. Furthermore, the treated EPE extract on zebrafish model was improved the ethanol induced survival rate and attenuated, oxidative stress and cell death. As well this result indicated that EPE extract rendered the protective effect of EPE extract against ethanol induced oxidative stress in vitro and zebrafish model. (C) 2013 Elsevier Ltd. All rights reserved.
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