Journal
JOURNAL OF FUNCTIONAL FOODS
Volume 5, Issue 4, Pages 1601-1610Publisher
ELSEVIER
DOI: 10.1016/j.jff.2013.07.002
Keywords
Lycopene; Liver; Antioxidants; Stress oxidative
Categories
Funding
- Junta de Extremadura (FEDER funds) [PRI07A041, GR10139]
- UEX
- Junta de Extremadura
- MICINN
- FEDER
- FEDER and FSE
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Lycopene, the major carotenoid in tomatoes, is a known antioxidant that may lower oxidative stress biomarkers by a mechanism that is not fully elucidated. The intoxication of rats with carbon tetrachloride (CCl4) resulted in significant histological hepatic degradation accompanied by a marked increase in reactive oxygen species (ROS) and in the number of apoptotic cells. The induced oxidative stress in turn results in a significant elevation of lipid peroxidation and H2O2 generation, together with a decrease in the concentration of reduced glutathione (GSH) and a significant reduction in activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and glutathione S transferase (GST). CCl4-intoxicated rats, pre-treated with lycopene, showed strongly reduced cell damage and ROS generation. The level of markers for hepatic integrity in lycopene pre-treated rats was close to the controls in the absence of CCl4 treatment, indicating the protective effect of lycopene pre-treatment. In the same way, lycopene pre-treated rats significantly increased SOD, CAT, GPx, GST activities and GSH level. In addition, we measured an increased lipoxygenase (LOX) activity in CCl4-intoxicated rats. This activity was reduced in lycopene pre-treated rats to values close to those observed in the controls, suggesting a potential pharmacological application of this dietary carotenoid. (C) 2013 Elsevier Ltd. All rights reserved.
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