Journal
JOURNAL OF FUNCTIONAL FOODS
Volume 5, Issue 3, Pages 1180-1190Publisher
ELSEVIER
DOI: 10.1016/j.jff.2013.04.001
Keywords
Cultivated seaweeds; Chondrus crispus; Functional foods; Caenorhabditis elegans; Stress tolerance
Categories
Funding
- Natural Sciences and Engineering Research Council of Canada (NSERC)
- Atlantic Canada Opportunities Agency (ACOA)
- Nova Scotia Department of Agriculture and Marketing (NSDAF)
- Acadian Seaplants Limited
- NSERC-IRDF Synergy Award
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Seaweeds are rich sources of bioactive compounds with potential health benefits. Anti-stress effects of the cultivated red alga, Chondrus crispus, were investigated in the Caenorhabditis elegans model. Methanolic extracts of C. crispus (CCME) enhanced C. elegans tolerance to juglone-induced oxidative stress and increased life span; however water extracts did not show such effects. CCME treatment reduced reactive oxygen species (ROS) in the worms and increased the transcription of stress response genes; sod3, hsp16.2, daf16 and skn1. The chemical profile of CCME revealed the presence of unsaturated fatty acids, pigments, galactolipids, floridoside, isothionic acid, taurine, phenylalanine and L-citruline. Bioassay guided fractionation revealed that fatty acids, lipids and pigments imparted stress tolerance. Taken together, our results suggest that organic fractions of cultivated C. crispus impart oxidative stress tolerance in C. elegans, possibly by altering the stress response pathways. (C) 2013 Elsevier Ltd. All rights reserved.
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