Journal
JOURNAL OF FUNCTIONAL FOODS
Volume 4, Issue 2, Pages 403-422Publisher
ELSEVIER
DOI: 10.1016/j.jff.2012.01.008
Keywords
Dipeptidyl peptidase (DPP)-IV; Inhibitor; In silico analysis; Dietary protein; Bioactive peptide
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Funding
- Natural Sciences and Engineering Council of Canada (NSERC)
- NSERC
- Canadian Dairy Commission
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Synthetic inhibitors against the enzyme dipeptidyl peptidase (DPP)-IV, a serine protease implicated in the inactivation of incretin hormones, are currently used for the management of type 2 diabetes. The aim of the present study was to evaluate the potential of dietary proteins from various food commodities to serve as precursors of DPP-IV inhibitors by using an in silico approach. A total of 2256 fragments with peptide sequences matching those reported in the literature to present DPP-IV inhibitory activity were found in the 34 proteins that were investigated. Among those, Gly-Ala, Gly-Pro and Pro-Gly were the most frequently occurring sequences. Caseins from cow's milk and collagens from bovine meat and salmon appeared to be the richest potential sources of DPP-IV inhibitors, whereas proteins from oat showed lower occurrence frequency values. This study suggests that dietary proteins could be used for generating DPP-IV inhibitory peptides. (C) 2012 Elsevier Ltd. All rights reserved.
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