Journal
MEDCHEMCOMM
Volume 5, Issue 9, Pages 1364-1370Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4md00197d
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Funding
- Natural Sciences and Engineering Research Council of Canada
- Canadian Institutes of Health Research
- American Chemical Society Petroleum Research Fund
- Ontario Graduate Scholarship
- Canada Research Chair in Drug Development
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The synthesis of N-cyanobenzo[b]carbazoloquinone 4, an isosteric-isoelectronic analogue of prekinamycin, is described. Cytotoxicity studies with K562 human leukemia cells reveal that the cyanamide analogue has a bioactivity profile similar to that of prekinamycin. These results indicate that the diazo functionality may not be an absolute requirement for bioactivity.
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