Journal
MEDCHEMCOMM
Volume 4, Issue 1, Pages 175-179Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2md20196h
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Funding
- European Research Council [240356]
- Israel Science Foundation [749/09]
- Edmond J. Safra Center for the Design and Engineering of Functional Biopolymers in the Negev
- European Research Council (ERC) [240356] Funding Source: European Research Council (ERC)
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Sulforaphane and erucin, two natural isothiocyanates that are highly abundant in broccoli and other cruciferous vegetables, were found to strongly inhibit quorum sensing and virulence in Pseudomonas aeruginosa. Mechanistic evaluations of these effects suggest that these isothiocyanates are antagonists of the transcriptional activator LasR.
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