Journal
MEDCHEMCOMM
Volume 4, Issue 10, Pages 1354-1359Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3md00219e
Keywords
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Funding
- NIH [PO1 AI057788, P30DK56338]
- Robert Welch Foundation [Q1279]
- Caroline Wiess Law Fund for Molecular Medicine
- Texas Medical Center Digestive Disease Center
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The protease of norovirus, an important human pathogen, is essential for the viral replication and, therefore, represents a potential drug target. A series of tripeptide-based inhibitors of the protease were designed, synthesized and tested, among which several potent inhibitors were identified with K-i values as low as 75 nM. The structure-activity relationships of these inhibitors are discussed.
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