Journal
MEDCHEMCOMM
Volume 4, Issue 6, Pages 956-961Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3md00077j
Keywords
-
Funding
- Cancer Research at Bath (CR@B)
- University of Bath
- RCUK
Ask authors/readers for more resources
The synthesis and antiproliferative activity of eleven 3-(pyrid-2-yl)-pyrazolines in two cancer cell lines are reported. X-ray crystallography was obtained of the lead compound 8i which was screened in the NCI 60 human tumour cell line and displayed sub-micromolar activity. Cell cycle analysis, in vitro tubulin assay and confocal microscopy are also reported and suggest that the lead compound disrupts microtubule formation.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available