4.1 Article

Design, synthesis and biological evaluation of novel indano- and thiaindano-pyrazoles with potential interest for Alzheimer's disease

Journal

MEDCHEMCOMM
Volume 4, Issue 6, Pages 925-931

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c3md00041a

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Funding

  1. Ministere Francais de l'Enseignement Superieur et de la Recherche
  2. Conseil Regional de Basse Normandie (Dispositif de Soutien aux Projets de Recherche Emergents)

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The synthesis of eighteen novel (thia)indanopyrazole derivatives was achieved starting from amino(thia)indanones. Some of them displayed a dual binding site acetylcholinesterase inhibition which makes them potentially interesting for Alzheimer's disease treatment.

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