Journal
MEDCHEMCOMM
Volume 4, Issue 6, Pages 972-978Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3md00055a
Keywords
-
Ask authors/readers for more resources
Regio- and stereoselective 1,3-dipolar cycloadditions of C-(chrom-4-one-3-yl)-N-phenylnitrones (5) with different mono-substituted, disubstituted and cyclic dipolarophiles were carried out to obtain substituted N-phenyl-3'-(chrom-4-one-3-yl)-isoxazolidines (7a-p, 10a-c and 12a-c). Some of the obtained isoxazolidines display significant cytotoxicity against several human cancer cell lines. The preliminary bioassay results revealed that compound 10c showed higher cytotoxicity than paclitaxel against the A549 cell line with an IC50 value of 0.7 mu M. Compound 10c induces apoptosis through a mitochondrial-dependent pathway in human promyelocytic leukemia (HL-60) cells as revealed by induced apoptotic bodies' formation, DNA ladder, increased Sub-G(0) DNA fraction and loss of mitochondrial membrane potential (Delta Psi(m)) in HL-60 cells.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available